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vate the transcription of the BCAT2 gene. For example, the expression of BCAT2 was decreased in KLF15-KO mice, and the rat BCAT2 promoter was activated by KLF15 and GR. Moreover, PPARa activated the BCKDH complex in the liver. In addition, bioinformatics analysis revealed that several nuclear receptors, including PPAR and estrogen receptor-related receptor, are significantly frequently recruited t